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What are diclofenac tablets?

DICLOFENAC (Voltaren®) is an anti-inflammatory drug. Diclofenac reduces the joint pain, stiffness, inflammation, or swelling caused by rheumatoid arthritis (rheumatism) and osteoarthritis. Generic diclofenac delayed-release tablets are available.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
• asthma, especially aspirin sensitive asthma
• bleeding problems or taking medicines that make you bleed more easily such as anticoagulants (‘blood thinners’)
• cigarette smoker
• coronary artery bypass graft (CABG) surgery within the past 2 weeks
• dental disease
• diabetes
• drink more than 3 alcohol-containing beverages a day
• heart or circulation problems like angina, high blood pressure, heart failure, heart rhythm problems, history of heart attack, history of blood clots, or leg edema (fluid retention)
• kidney disease
• liver disease
• porphyria
• stomach or duodenal ulcers
• history of stroke
• systemic lupus erythematosus
• ulcerative colitis
• an unusual or allergic reaction to diclofenac, aspirin, other salicylates, other NSAIDs, other medicines, foods, dyes or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I take this medicine?

Take diclofenac tablets by mouth. Follow the directions on the prescription label. Swallow tablets whole with a full glass of water; take tablets in an upright or sitting position. Do not crush or chew tablets. Taking a sip of water first, before taking the tablets, may help you swallow them. It is better to take diclofenac with food. Take your doses at regular intervals. Do not take your medicine more often than directed.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What drug(s) may interact with diclofenac?

• alcohol
• alendronate
• aspirin and aspirin-like medicines
• cidofovir
• cyclosporine
• drospirenone; ethinyl estradiol (Yasmin®)
• entecavir
• herbal products that contain feverfew, garlic, ginger, or ginkgo biloba
• lithium
• medicines for high blood pressure
• medicines that affect platelets
• medicines that treat or prevent blood clots such as warfarin and other ‘blood thinners’
• methotrexate
• other antiinflammatory drugs (such as ibuprofen or prednisone)
• pemetrexed
• water pills (diuretics)

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What side effects may I notice from taking diclofenac?

Elderly patients are at increased risk for developing side effects.

Side effects that you should report to your prescriber or health care professional as soon as possible:
• signs of bleeding from the stomach – black tarry stools, blood in the urine, unusual tiredness or weakness, vomiting blood or vomit that looks like coffee grounds
• signs of an allergic reaction – difficulty breathing or wheezing, skin rash, redness, blistering or peeling skin, hives, or itching, swelling of eyelids, throat, lips
• change in the amount of urine passed
• difficulty swallowing, severe heartburn or burning, pain in throat
• pain or difficulty passing urine
• stomach pain or cramps
• swelling of feet or ankles
• yellowing and/or itching of eyes or skin, upper right abdominal/chest tenderness, fatigue

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
• constipation or diarrhea
• dizziness
• gas or heartburn
• headache
• nausea, vomiting

What should I watch for while taking diclofenac?

Let your prescriber or health care professional know if your pain continues, do not take with other pain-killers without advice. If you get flu-like symptoms (fever, chills, muscle aches and pains), call your prescriber or health care professional; do not treat yourself.

To reduce unpleasant effects on your throat and stomach, take diclofenac with a full glass of water and never just before lying down. If you notice black, tarry stools or experience severe stomach pain and/or vomit blood or what looks like coffee grounds, notify your health care prescriber immediately.

If you are taking medicines that affect the clotting of your blood, such as aspirin or blood thinners such as Coumadin®, talk to your health care provider or prescriber before taking this medicine.

You may get dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how diclofenac affects you. Do not sit or stand up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.

Do not smoke cigarettes or drink alcohol; these increase irritation to your stomach and can make it more susceptible to damage from diclofenac.

If you are going to have surgery, tell your prescriber or health care professional that you are taking diclofenac. Diclofenac can cause you to bleed more easily. Problems can arise if you need dental work, and in the day to day care of your teeth. Try to avoid damage to your teeth and gums when you brush or floss your teeth.

It is especially important not to use diclofenac during the last 3 months of pregnancy unless specifically directed to do so by your health care provider. Diclofenac may cause problems in the unborn child or complications during delivery.

Where can I keep my medicine?

Keep out of the reach of children in a container that small children cannot open.

Store at room temperature below 30 degrees C (86 degrees F). Protect from moisture. Keep container tightly closed. Throw away any unused medicine after the expiration date.

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Celecoxib is used for:

Treating rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual pain, or pain. It is used in familial adenomatous polyposis (FAP) to decrease the number of polyps (growths) in the rectal area. It may also be used for other conditions as determined by your doctor.

Celecoxib is a COX-2 inhibitor NSAID. Exactly how it works is not known. It may block certain substances in the body that are linked to inflammation. NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.

Do NOT use Celecoxib if:

• you are allergic to any ingredient in Celecoxib
• you have had a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin, an NSAID (eg, ibuprofen), or a sulfonamide (eg, sulfamethoxazole)
• you have recently had or will be having bypass heart surgery
• you have severe liver problems
• you are in the last 3 months of pregnancy

Contact your doctor or health care provider right away if any of these apply to you.

Before using Celecoxib :

Some medical conditions may interact with Celecoxib. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal product, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of kidney or liver disease, diabetes, or stomach or bowel problems (eg, bleeding, perforation, ulcers)
• if you have a history of swelling or fluid buildup, asthma, growths in the nose (nasal polyps), or mouth inflammation
• if you have high blood pressure, blood disorders, bleeding or clotting problems, heart problems (eg, heart failure), or blood vessel disease, or if you are at risk for any of these diseases
• if you have poor health, dehydration or low fluid volume, or low blood sodium levels, you drink alcohol, or you have a history of alcohol abuse

Some MEDICINES MAY INTERACT with Celecoxib. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticoagulants (eg, warfarin), aspirin, corticosteroids (eg, prednisone), heparin, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because risk of stomach bleeding may be increased
• Fluconazole or probenecid because they may increase the risk of Celecoxib ’s side effects
• Cyclosporine, lithium, methotrexate, or quinolones (eg, ciprofloxacin) because the risk of their side effects may be increased by Celecoxib
• Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) or diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness may be decreased by Celecoxib

This may not be a complete list of all interactions that may occur. Ask your health care provider if Celecoxib may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Celecoxib :

Use Celecoxib as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Celecoxib comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Celecoxib refilled.
• Take Celecoxib by mouth. It may be taken with food if it upsets your stomach. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.
• Some doses of Celecoxib should be taken with food. Ask your doctor if you have questions about how to take Celecoxib.
• Take Celecoxib with a full glass of water (8 oz/240 mL) as directed by your doctor.
• Do not lie down for 30 minutes after you take Celecoxib.
• If you miss a dose of Celecoxib and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about the proper use of Celecoxib.

Important safety information:

• Celecoxib may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Celecoxib with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Serious stomach ulcers or bleeding can occur with the use of Celecoxib. Taking it in high doses, for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Celecoxib with food will NOT reduce the risk of these effects. If you have severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling, contact your doctor or emergency room right away.
• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor
• Celecoxib is an NSAID. Before you start any new medicine, check the label to see if it has an NSAID (eg, ibuprofen) in it too. If it does or if you are not sure, check with your doctor or pharmacist.
• Do not take aspirin while you are using Celecoxib unless your doctor tells you to.
• FAP patients �Celecoxib has not been shown to reduce FAP-related cancers or the need for other procedures or surgeries. Continue your usual care while you use Celecoxib.
• Lab tests, including kidney function, complete blood cell counts, and blood pressure, may be performed while you use Celecoxib. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Use Celecoxib with caution in the ELDERLY; they may be more sensitive to its effects, especially stomach bleeding and kidney problems.
• Celecoxib should be used with extreme caution in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: Celecoxib may cause harm to the fetus. Do not use it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Celecoxib while you are pregnant. Celecoxib is found in breast milk. Do not breast-feed while taking Celecoxib.

Possible side effects of Celecoxib :

All medicines can cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; gas; headache; heartburn; nausea; sore throat; stomach upset; stuffy nose.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; dark urine; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; hearing loss; mental or mood changes; numbness of an arm or leg; one-sided weakness; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting; shortness of breath; sudden or unexplained weight gain; swelling of hands, legs, or feet; unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds; yellowing of the skin or eyes.

What is the shelf life of the pills?

• The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.

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What is/are Probenecid Tablets?

PROBENECID helps to remove excess uric acid from the body. This medicine is used to prevent gouty attacks. It is also used to increase the amount of time that some antibiotics stay in the body. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care providers before I take this medicine?

They need to know if you have any of these conditions:

acute gouty attack blood disorders or disease kidney disease, or kidney stones recent radiation therapy stomach ulcers an unusual or allergic reaction to probenecid, sulfa drugs, other medicines, foods, dyes, or preservatives pregnant or trying to get pregnant breast-feeding

How should I use this medicine?

Take this medicine by mouth with a full glass of water. Follow the directions on the prescription label. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor’s advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. Do not use this medicine in children under 2 years old.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

Note: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following:

aspirin and aspirin-like medicines ketorolac methotrexate topiramate

This medicine may also interact with the following:

acetaminophen alcohol antibiotics including penicillins, sulfonamides antiviral medicines such as acyclovir, famciclovir, ganciclovir lorazepam meclofenamate medicines for diabetes medicines for sleep during surgery NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen pyrazinamide rifampin

This list may not describe all possible interactions. Give your health care providers a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What side effects may I notice from this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue blood in urine breathing difficulty fever, chills, infection lower back or side pain pain, difficulty passing urine painful, swollen joints unusual bleeding or bruising unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

dizzy flushing frequent passing of urine hair loss headache loss of appetite nausea, vomiting sore gums

This list may not describe all possible side effects.

What should I watch for while using this medicine?

It may take several months before you see the full effect of this medicine. It is only effective if you keep taking it regularly even if you have an attack of gout. Your prescriber or health care professional will prescribe other tablets to treat an acute attack.

Aspirin and non-steroidal antiinflammatory drugs like ibuprofen can make this medicine less effective. Do not treat yourself for headaches or pain. Ask your doctor or health care professional for advice.

Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

You may need to be on a special diet while taking this medicine. Check with your doctor. Also, ask how many glasses of fluid you need to drink a day. You must not get dehydrated.

This medicine can interfere with some urine glucose tests. If you use such tests talk with your health care professional.

Where should I keep this medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.

What is the shelf life of the pills?

• The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.

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What is the shelf life of the pills?

• The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.

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Mefenamic Acid is used for:

Treating menstrual pain. It may be used for short term (not more than 7 days) treatment of mild to moderate pain. It may also be used for other conditions as determined by your doctor.

Mefenamic Acid is an NSAID. Exactly how it works is not known. It may block certain substances in the body that are linked to inflammation. NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.

Do NOT use Mefenamic Acid if:

• you are allergic to any ingredient in Mefenamic Acid
• you have had a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or a nonsteroidal anti-inflammatory drug (NSAID) (eg, ibuprofen, celecoxib)
• you have recently had or will be having bypass heart surgery
• you have kidney problems, ulcers, or inflammation of the stomach or bowel
• you are in the last 3 months of pregnancy

Contact your doctor or health care provider right away if any of these apply to you.

Before using Mefenamic Acid :

Some medical conditions may interact with Mefenamic Acid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of liver disease, diabetes, or stomach or bowel problems (eg, bleeding, perforation, ulcers)
• if you have a history of swelling or fluid buildup, asthma, growths in the nose (nasal polyps), or mouth inflammation
• if you have high blood pressure, blood disorders (eg, porphyria), bleeding or clotting problems, heart problems (eg, heart failure), or blood vessel disease, or if you are at risk for any of these diseases
• if you have poor health, dehydration or low fluid volume, or low blood sodium levels, you drink alcohol, or you have a history of alcohol abuse

Some MEDICINES MAY INTERACT with Mefenamic Acid. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticoagulants (eg, warfarin), aspirin, corticosteroids (eg, prednisone), heparin, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because the risk of stomach bleeding may be increased
• Magnesium hydroxide (eg, antacids) or probenecid because they may increase the risk of Mefenamic Acid ’s side effects
• Cyclosporine, lithium, methotrexate, quinolones (eg, ciprofloxacin), or sulfonylureas (eg, glipizide) because the risk of their side effects may be increased by Mefenamic Acid
• Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) or diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness may be decreased by Mefenamic Acid

This may not be a complete list of all interactions that may occur. Ask your health care provider if Mefenamic Acid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Mefenamic Acid :

Use Mefenamic Acid as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Mefenamic Acid comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Mefenamic Acid refilled.
• Take Mefenamic Acid by mouth. It may be taken with food if it upsets your stomach. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.
• Take Mefenamic Acid with a full glass of water (8 oz/240 mL) as directed by your doctor.
• If you miss a dose of Mefenamic Acid and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Mefenamic Acid.

Important safety information:

• Mefenamic Acid may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Mefenamic Acid with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Serious stomach ulcers or bleeding can occur with the use of Mefenamic Acid. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Mefenamic Acid with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.
• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
• Mefenamic Acid is an NSAID. Before you start any new medicine, check the label to see if it has an NSAID (eg, ibuprofen) in it too. If it does or if you are not sure, check with your doctor or pharmacist.
• Do not take aspirin while you are using Mefenamic Acid unless your doctor tells you to.
• Mefenamic Acid may interfere with certain lab tests. Be sure your doctor and lab personnel know that you take Mefenamic Acid.
• Lab tests, including kidney function, complete blood cell counts, and blood pressure, may be performed while you use Mefenamic Acid. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Use Mefenamic Acid with caution in the ELDERLY; they may be more sensitive to its effects, especially stomach bleeding and kidney problems.
• Mefenamic Acid should be used with extreme caution in CHILDREN younger than 14 years old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: Mefenamic Acid may cause harm to the fetus. Do not use it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Mefenamic Acid while you are pregnant. Mefenamic Acid is found in breast milk. Do not breast-feed while taking Mefenamic Acid.

Possible side effects of Mefenamic Acid :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; gas; headache; heartburn; nausea; stomach upset.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; dark urine; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting; shortness of breath; sudden or unexplained weight gain; swelling of hands, legs, or feet; unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds; yellowing of the skin or eyes.

What is the shelf life of the pills?

• The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.

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What is the shelf life of the pills?

• The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.

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What is/are Naproxen Tablets?

NAPROXEN is a non-steroidal anti-inflammatory drug (NSAID). It is used to reduce swelling and to treat pain. This medicine may be used for dental pain, headache, or painful monthly periods. It is also used for painful joint and muscular problems such as arthritis, tendinitis, bursitis, and gout. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care providers before I take this medicine?

They need to know if you have any of these conditions:

• asthma
• cigarette smoker
• drink more than 3 alcohol containing drinks a day
• heart disease or circulation problems such as heart failure or leg edema (fluid retention)
• high blood pressure
• kidney disease
• liver disease
• stomach bleeding or ulcers
• an unusual or allergic reaction to naproxen, aspirin, other NSAIDs, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take it with food if your stomach gets upset. Try to not lie down for at least 10 minutes after you take it. Take your medicine at regular intervals. Do not take your medicine more often than directed. Long-term, continuous use may increase the risk of heart attack or stroke.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

Note: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

• alcohol
• aspirin
• cidofovir
• diuretics
• lithium
• methotrexate
• other drugs for inflammation like ketorolac or prednisone
• pemetrexed
• probenecid
• warfarin

This list may not describe all possible interactions. Give your health care providers a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What side effects may I notice from this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

• black or bloody stools, blood in the urine or vomit
• blurred vision
• chest pain
• difficulty breathing or wheezing
• nausea or vomiting
• severe stomach pain
• skin rash, skin redness, blistering or peeling skin, hives, or itching
• slurred speech or weakness on one side of the body
• swelling of eyelids, throat, lips
• unexplained weight gain or swelling
• unusually weak or tired
• yellowing of eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

• constipation
• headache
• heartburn

This list may not describe all possible side effects.

What should I watch for while using this medicine?

Tell your doctor or health care professional if your pain does not get better. Talk to your doctor before taking another medicine for pain. Do not treat yourself.

This medicine does not prevent heart attack or stroke. In fact, this medicine may increase the chance of a heart attack or stroke. The chance may increase with longer use of this medicine and in people who have heart disease. If you take aspirin to prevent heart attack or stroke, talk with your doctor or health care professional.

Do not take ibuprofen with this medicine. Side effects such as stomach upset, nausea, or ulcers may be more likely to occur. Many medicines available without a prescription should not be taken with this medicine.

This medicine can cause ulcers and bleeding in the stomach and intestines at any time during treatment. Do not smoke cigarettes or drink alcohol. These increase irritation to your stomach and can make it more susceptible to damage from this medicine. Ulcers and bleeding can happen without warning symptoms and can cause death.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.

This medicine can cause you to bleed more easily. Try to avoid damage to your teeth and gums when you brush or floss your teeth.

Where should I keep this medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.

What is the shelf life of the pills?

• The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.

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What is/are Cataflam Tablets?

DICLOFENAC is a non-steroidal anti-inflammatory drug (NSAID). It is used to reduce swelling and to treat pain. It may be used to treat osteoarthritis, rheumatoid arthritis, mild to moderate pain, and painful monthly periods. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care providers before I take this medicine?

They need to know if you have any of these conditions:

• asthma, especially aspirin sensitive asthma
• coronary artery bypass graft (CABG) surgery within the past 2 weeks
• drink more than 3 alcohol containing drinks a day
• heart disease or circulation problems like heart failure or leg edema (fluid retention)
• high blood pressure
• kidney disease
• liver disease
• stomach bleeding or ulcers
• an unusual or allergic reaction to diclofenac, aspirin, other NSAIDs, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medicine?

Take this medicine by mouth with food and with a full glass of water. Follow the directions on the prescription label. Take your medicine at regular intervals. Do not take your medicine more often than directed. Long-term, continuous use may increase the risk of heart attack or stroke.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Elderly patients over 65 years old may have a stronger reaction and need a smaller dose.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

Note: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following:

• cidofovir
• ketorolac
• methotrexate
• pemetrexed

This medicine may also interact with the following:

• alcohol
• aspirin and aspirin-like medicines
• diuretics
• lithium
• medicines for high blood pressure
• medicines that affect platelets
• medicines that treat or prevent blood clots like warfarin
• NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
• steroid medicines like prednisone or cortisone

This list may not describe all possible interactions. Give your health care providers a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What side effects may I notice from this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
• black or bloody stools, blood in the urine or vomit
• blurred vision
• chest pain
• difficulty breathing or wheezing
• nausea or vomiting
• slurred speech or weakness on one side of the body
• unexplained weight gain or swelling
• unusually weak or tired
• yellowing of eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

• constipation
• diarrhea
• dizziness
• headache
• heartburn

This list may not describe all possible side effects.

What should I watch for while using this medicine?

Tell your doctor or health care professional if your pain does not get better. Talk to your doctor before taking another medicine for pain. Do not treat yourself.

This medicine does not prevent heart attack or stroke. In fact, this medicine may increase the chance of a heart attack or stroke. The chance may increase with longer use of this medicine and in people who have heart disease. If you take aspirin to prevent heart attack or stroke, talk with your doctor or health care professional.

Do not take medicines such as ibuprofen and naproxen with this medicine. Side effects such as stomach upset, nausea, or ulcers may be more likely to occur. Many medicines available without a prescription should not be taken with this medicine.

This medicine can cause ulcers and bleeding in the stomach and intestines at any time during treatment. Do not smoke cigarettes or drink alcohol. These increase irritation to your stomach and can make it more susceptible to damage from this medicine. Ulcers and bleeding can happen without warning symptoms and can cause death.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.

This medicine can cause you to bleed more easily. Try to avoid damage to your teeth and gums when you brush or floss your teeth.

Where should I keep this medicine?

Keep out of the reach of children.

Store at room temperature below 30 degrees C (86 degrees F). Protect from moisture. Keep container tightly closed. Throw away any unused medicine after the expiration date. ,

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Ibuprofen is used for:

Treating rheumatoid arthritis, osteoarthritis, menstrual cramps, or mild to moderate pain. It may also be used for other conditions as determined by your doctor.

Ibuprofen is an NSAID. Exactly how it works is not known. It may block certain substances in the body that are linked to inflammation. NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.

Do NOT use Ibuprofen if:

• you are allergic to any ingredient in Ibuprofen
• you have had a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or an NSAID (eg, ibuprofen, celecoxib)
• you have recently had or will be having bypass heart surgery
• you are in the last 3 months of pregnancy

Contact your doctor or health care provider right away if any of these apply to you.

Before using Ibuprofen :

Some medical conditions may interact with Ibuprofen. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal product, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of kidney or liver disease, diabetes, or stomach or bowel problems (eg, bleeding, perforation, ulcers)
• if you have a history of swelling or fluid buildup, lupus, asthma, or growths in the nose (nasal polyps), or mouth inflammation
• if you have high blood pressure, blood disorders, bleeding or clotting problems, heart problems (eg, heart failure), or blood vessel disease, or if you are at risk for any of these diseases
• if you have poor health, dehydration or low fluid volume, or low blood sodium levels, you drink alcohol, or you have a history of alcohol abuse

Some MEDICINES MAY INTERACT with Ibuprofen. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticoagulants (eg, warfarin), aspirin, corticosteroids (eg, prednisone), heparin, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because the risk of stomach bleeding may be increased
• Probenecid because it may increase the risk of Ibuprofen ’s side effects
• Cyclosporine, lithium, methotrexate, or quinolones (eg, ciprofloxacin) because the risk of their side effects may be increased by Ibuprofen
• Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) or diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness may be decreased by Ibuprofen

This may not be a complete list of all interactions that may occur. Ask your health care provider if this medicine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Ibuprofen :

Use Ibuprofen as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Ibuprofen comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Ibuprofen refilled.
• Take Ibuprofen by mouth with or without food. It may be taken with food if it upsets your stomach. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.
• Take Ibuprofen with a full glass of water (8 oz/240 mL) as directed by your doctor.
• If you miss a dose of Ibuprofen and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about the proper use of Ibuprofen.

Important safety information:

• Ibuprofen may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Ibuprofen with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Serious stomach ulcers or bleeding can occur with the use of Ibuprofen. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Ibuprofen with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.
• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
• Ibuprofen has ibuprofen in it. Before you start any new medicine, check the label to see if it has ibuprofen in it too. If it does or if you are not sure, check with your doctor or pharmacist.
• Do not take aspirin while you are using Ibuprofen unless your doctor tells you to.
• Lab tests, including kidney function, complete blood cell counts, and blood pressure, may be done to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
• Use Ibuprofen with caution in the ELDERLY; they may be more sensitive to its effects, including stomach bleeding and kidney problems.
• Ibuprofen should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: Ibuprofen may cause harm to the fetus. Do not take it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Ibuprofen while you are pregnant. It is not known if Ibuprofen is found in breast milk. Do not breast-feed while taking Ibuprofen.

Possible side effects of Ibuprofen :

All medicines can cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; gas; headache; heartburn; nausea; stomach pain or upset.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; dark urine; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting; shortness of breath; stiff neck; sudden or unexplained weight gain; swelling of hands, legs, or feet; unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds; yellowing of the skin or eyes.

What is the shelf life of the pills?

• The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.

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Drug Name

Benemid (Probenecid)

Drug Uses

Benemid is used in the treatment of chronic gout or gouty arthritis. These conditions are caused by too much uric acid in the blood.

How Taken

Use Benemid as directed by your doctor.

Take Benemid tablets by mouth.

Swallow the tablets with a drink of water.

Take your doses at regular intervals.

Ask your health care provider any questions you may have about how to use Benemid.

Drug Class and Mechanism

Benemid works by removing the extra uric acid from the body. Benemid does not cure gout, but after you have been taking it for a few months it will help prevent gout attacks. Benemid will help prevent gout attacks only as long as you continue to take it.

Benemid is also used to prevent or treat other medical problems that may occur if too much uric acid is present in the body.

Benemid is sometimes used with certain kinds of antibiotics to make them more effective in the treatment of infections.

Missed Dose

If you miss a dose of Benemid, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Storage

Store Benemid at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Benemid out of the reach of children and away from pets.

Warnings/Precautions

Do not use Benemid if:

• you are allergic to any ingredient in Benemid;
• you have blood problems or kidney stones caused by uric acid;
• the patient is a child younger than 2 years of age;
• you are taking salicylates (e.g., aspirin).

Contact your doctor or health care provider right away if any of these apply to you.

Important:

Benemid may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Benemid. Using Benemid alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.

Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Benemid.

Diabetes patients – Benemid may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.

Benemid may interfere with some lab tests (e.g., blood or hemoglobin urine tests, theophylline levels). Make sure your doctor and lab personnel know you are using Benemid.

Lab tests, including tests for sugar in the urine, may be required to monitor your progress. Be sure to keep all doctor and lab appointments.

Use of Benemid is not recommended in children younger than 2 years of age. Safety and effectiveness in this age group have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant while taking Benemid, discuss with your doctor the benefits and risks of using Benemid during pregnancy. Benemid is excreted in breast milk. If you are or will be breast-feeding while you are using Benemid, check with your doctor or pharmacist to discuss the risks to your baby.

Possible Side Effects

Check with your doctor if any of these most common side effects persist or become bothersome:

• dizziness;
• flushing;
• hair loss;
• headache; l
• oss of appetite;
• nausea;
• sore gums;
• vomiting.

Seek medical attention right away if any of these severe side effects occur:

• severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue);
• blood in the urine;
• chills;
• dark urine;
• decreased or increased urination;
• fever;
• lower back, lower stomach, genital, or inner thigh pain;
• persistent sore throat;
• severe or persistent nausea, vomiting, or stomach pain;
• unusual bleeding or bruising;
• unusual tiredness or weakness;
• worsening gout;
• yellowing of the eyes or skin.

More Information

Benemid is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

What is the shelf life of the pills?

• The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.

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